Research of additive manufacturing of biodegradable magnesium alloys and their applications in implantology and regenerative medicine
| Acronym: | MAG3DP |
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| Project start: | 01.07.2018 |
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| Project end: | 30.06.2022 |
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| Programme: | APVV |
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| Project number: | APVV-17-0278 |
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| Institute position in the project: | Partner |
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| Project leader at the institute: | Milan Škrobian |
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Nowadays, the current trend in implant production using additive technologies respectively 3D printing is the application of biodegradable or partially degradable materials, that promote osteoinduction and osteoconduction while allowing minimization of surgical procedures. One of the alternative in this field is the use of magnesium alloys that have sufficient mechanical properties, controllable biodegradability, and are transparent for postoperative medical diagnostics as CT and MRI. The main objective of the project is to develop magnesium alloys in the form of powders, with complete elimination of negative properties described in publications such as fast corrosion rate and therefore degradation of material, with release of undesirable hydrogen. At the same time, an SLM additive production machine will be technically adapted for the processing of highly reactive magnesium and its alloys for additional production of samples for further material, mechanical and biological testing. In the final phase of the project, two types of implants will be made from developed alloys. Temporary substitutions of hard tissue, respectively osteosynthetic apparatus in the role of bone support with complete degradation function - biological degradation of the material without the need for reoperation in the form of screws for the area of orthopedics. The research team has an ambition to produce permanent implants with a partial degradation of material and biointegration of the surrounding tissue for neurosurgery and maxillofacial surgery from developed alloys. In the final phase of the project, it is planned to prepare preclinical and clinical experiments as a phase of initiatial application of developed alloys in the form of medical devices into clinical practice.